CurQfen® - www.curqfen.net
The poor oral bioavailability contributed by the insolubility and rapid biotransformation has been established as the major limitation for the ‘functional’ or ‘nutraceutical’ applications of curcumin. Though a number of bioavailable formulations with enhanced bioavailability of ‘curcumin metabolites’ have been reported and available commercially, oral delivery forms capable of providing curcuminoids in its native bioactive forms as ‘free (unconjugated)’ curcuminoids remains as a challenge.
Recent understanding on the relative bioactivity and permeability of ‘free’ curcuminoids have demonstrated that curcuminglucuronides (major conjugated metabolites) possess no anticancer, anti-inflammatory and antioxidant activities (Bioorg. Med. Chem. 2014, 22, 435; Food Chem, 2014, 151, 126; Antioxidants, 2015, ISSN-2937) and low membrane permeability(J Pharmacol. Exptl Therapeutics, 2008, 326, 196). Thus, the key factor responsible for the efficacy of a curcumin formulation is turned out to be the “free curcuminoids availability” in plasma and its cellular distribution. The mere number of folds of bioavailability as determined by the area under curve of curcumin metabolites in plasma as reported so far became questionable.
CurQfen® is a ‘new generation’ bioavailable curcumin, capable of providing ‘free’ curcuminoids into plasma and further into organ tissues with improved BLOOD-BRAIN-BARRIER permeability (Journal of Functional Foods, 2015, 14, 215). CurQfen® is a 100% natural, food-grade and non-NANO formulation prepared by a GREEN process (patented) employing only water (FenuMATTM technology). Various animal and human studies have also demonstrated ‘free’ curcuminoids bioavailability (45.5-fold), pharmacokinetics, relative distribution of ‘free’ curcuminoids (>70%) (Journal of Functional Foods, 2016, 22, 578) and enhanced efficacy such as reduction in aortic stiffness among young obese people (study by University Kentucky, USA) (Journal of Functional Foods, 2017, 29, 154), reduction of stress/anxiety/fatigue (human) (J ClinPsychopharmacol, 2016, 36, 1), etc.
The novelty of CurQfen® mainly lies in the unique formulation using fenugreek galactomannan dietary fibre as a non-covalently linked “Curcumagalactomannoside” complex and its method of delivery without interfering with the detoxification enzymes. CurQfen® protects curcumin against the in vivo enzymatic biotransformation to curcumin metabolites being a macromolecular complex.CurQfen® has ‘self-affirmed GRAS’, published safety studies in animals/humans and suitable forchocolates/cereal bars/sachets/soups/ yogurts/gummies etc, in addition to capsules/tablets/soft gels/brisk effervescence forms.
Radiotherapy induces significant damage to immune system by affecting lymphocytes (T cells, B cells and natural killer cells), mono cystes, macrophages, antigen-presenting cells (APCs) etc. Though curcumin has been shown to have some degree of radioprotective effects, it was always hampered by the poor bioavailability and cellular uptake. Recent study published in ‘Nutrition & Cancer’ demons trated the ENHANCED IMMUNO-PROTECTIVE & RADIOPROTECTIVE effects of CurQfen® by retaining ‘bone marrow cellularity’.
Clinically substantiated claims:
The statements made above have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
However, the very strong pungency, skin irritation, respiratory tract allergies, possible gastrointestinal mucosa bleeding and ulcers limits made it a forbidden limit!
Capsifen® - Designed and tailored to meet the challenges associated with the handling, safety and consumption of pungent capsaicinoids without compromising its physiological benefits. Capsifen® is the pure hydro-ethanolic extract of red chili peppers, formulated in the beadlet form, employing soluble dietary fiber (Galactomannans) isolated from the spice, Fenugreek (Trigonella foenum gracum). A patent pending technology was for the uniform impregnation of capsaicinoids in beadlet forms. The slow delivery of the actives in colloidal forms helps the better absorption into the blood stream. The beadlets masks the pungency effectively and helps the easy handling without any discomforts to the skin and respiratory tract.
Capsifen® the unique, sugar and gelatin free, commercially available standardized capsaicinoid beadlets works on a novel principle substantiated by in vitro/in vivo studies on delivery kinetics. At suitable concentrations for 100 to 250 mg dosage daily.
A recent Randomized-Controlled Trial has confirmed the bioavailability (absorption) of red chili extracted capsaicinoids followed by a single dose of 200 mg of Capsifen without causing any abdominal discomforts. Capsifen is the very first capsaicinoids formulation that has been shown to provide capsaicinoids in the systemic circulation..
BETTER ABSORPTION, BETTER EFFICACY & SAFE!
The study has also pointed towards the usefulness of Capsifen as a prewor kout agent in body weight management. 28-days of supplementation produced a physiologically significant decrease in body weight, w/h ratio, body mass index (BMI) and appetite. Capsifen Provides A Natural
Capsifen Provides A Natural Way to Burn Energy & Fat
Capsiten - Tailored to conquer the challenge ges associated with the oral delivery of pungent red chili pepper Capsaicinoids without compromising the physiological bene fits. Capsifen has used a targeted sustained intestinal delivery approach based on natural biopolymer and confirmation by Tandem mass spectrometry (UPLC ESI-QQQMS/MS).
Red chili peppers (Capsicum annum L and Capsicum frutescens) are rich in Capsaicinoids – naturally occurring vanilloids (capsaicin, dihydrocapsaicin, nordihydrocapsaicin) along with antioxidant carotenoids β-carotene, capsanthin and capsorubin1. Recent advances in the molecular events have identified the potential of capsaicinoids for therapeutic intervention against thermogenesis and enhanced energy expenditure. The additional benefits such as lipolysis which helps to lower the plasma triglyceride levels5, lipid oxidation and sense of satiety have positioned red chili derived capsaicinoids as an attractive nutritional ingredient in the fight against obesity2. Capsaicin also shows to enhance metabolic rate and body temperature4. It inhibits the nuclear transcription factors like NFkB and AP-1 to provide anti-inflammatory action6. Also induces apoptosis and inhibit prostate cancer cell and small cell lung cancer proliferation.
The statements made above have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
The thermal stability and water solubility of the product helps to incorporate in various food/beverages like juices, soft drinks, sachets, chocolates, protein bars, health supplements such as protein powders, athletic supplements etc. Aroma of the extract powder can be varied or even deflavoured to suit the end application.
Modern scientific research has delineated many of the physiological benefits of clove to its essential oil, mainly eugenol and acetyl eugenol content. However, the polyphenol load and its nexus with the physiological properties have been recently substantiated. Clovinol® is the true water soluble polyphenolic extract of clove buds developed through a patent pending hydro-ethanolic extraction process.
Modern scientific research has delineated many of the physiological benefits of clove to its essential oil, mainly eugenol and acetyl eugenol content. However, the polyphenol load and its nexus with the physiological properties have been recently substantiated. Clovinol® is the true water soluble polyphenolic extract of clove buds developed through a patent pending hydro-ethanolic extraction process.
The thermal stability and water solubility also makes this ingredient suitable to incorporate in various food/beverages like juices, soft drinks, sachets, chocolates, protein bars, sports health supplements etc. Aroma of the extract powder can be varied or even deflavoured to suit the end application. We make sure the raw material from the same location along with its unique post -harvest operations. Clovinol®, the very first commercially available standardized polyphenolic extract of clove buds that has shown to be safe and efficient at dosage 100 to 250 mg daily, prior to meal helps to maintain normal metabolism (unpublished data).
Clove buds are regarded as the champion of spices. Clovinol is a water-soluble polyphenolic extract of clove buds developed through a patent pending extraction technology.
The statements made above have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Dark violet red Hibiscus flowers are rich in bioactive anthocyanins, hydroxyl acids and
polyphenols. HiBCYN™represent a unique composition of Hibiscus flower derived
anthocyanins and hydroxyl acids (hibiscus acid) responsible for the anti-hypertensive and antioxidant
effects. Customized anthocyanin and hibiscus acid levels are the specialties of
HiBCYN™. It is also shown to be an effective urinary tract infection agent either alone
or in combination with other ingredients such as cranberry extracts. This water soluble extract can also
be used as a natural colour for various functional food/beverages and cosmetic ingredient. It is also a
suitable agent for lake colours.
The statements made above have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
procynCi® is a hydro-ethanolic extract of cinnamon containing 10% procyanidin type A polymer and a total polyphenol content greater than 70% catechin equivalent. It is manufactured under GMP conditions, employing a patent pending extraction process which helps in selective removal of toxic coumarins and cinnmaldehyde while purifying the bioactive procyanidins and polyphenols to highest degree of availability. LC/MS/MS characterization followed by quantification confirms the bioactive procyanidin trimers, tetramers and pentameters of type A and Type B and naturally occurring chromium.
The thermal stability and water solubility of the product helps to incorporate in various food/beverages like juices, soft drinks, sachets, chocolates, protein bars, health supplements such as protein powders, athletic supplements etc. Aroma of the extract powder can be varied or even deflavoured to suit the end application.
Decoumarinated & water-soluble extract rich in fully characterized Type-A polymers.
Our publications:
Modern scientific research delineated many of the physiological benefits of cinnamon to its procyanidin polyphenols1. However, the presence of inherent toxic coumarins closely associated with cinnamon procyanidins limited the wide spread use of cinnamon polyphenols as dietary supplements.
procynCi® the only extract shown to be safe upon genotoxicity studies (unpublished data). 250 to 500 mg daily, prior to meal helps to maintain normal metabolism.
The statements made above have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Cocoa beans form a panacea of antioxidant flavonoids, bioavailable procyanidin oligomers, and
prebiotics responsible for a wide range of health benefits, comprising cardio protective,
neuroprotective and cosmetic effects. KocaoX™ represents a unique blend of cocoa antioxidants and
cocoa soluble dietary fiber in a stable water soluble form for colloidal dispersion in the gut for
better absorption. Various grades of cocoa antioxidant extracts suitable for functional
food/diary/sachet/chocolate applications are available under the brand KocaoX™.
The statements made above have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
StabilRose™represents an array of standardized Rosemary derived natural
antioxidants for dietary supplements and food applications. The extracts standardized for highest levels
of Carnosic acid (> 60%) and Rosemarinic acid (>10%) are suitable for dietary supplements. While the
decolourised, and deodourised free flowing oil soluble and water soluble liquid extracts are suitable as
natural antioxidants for the preservation of food/meat/omega acids/ and other lipid containing food.
StabilRose™ is available in a wide range of powder and liquid form suitable for varying
applications.
The statements made above have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Recent advances in molecular nutrition and phyto-research has identified the molecule, 6-gingerol (1-(4'-hydroxy-3'-methoxyphenyl)-5-hydroxy-3-decanone) as the most potent and bioactive among the various gingerol isomers present in ginger11. A meta-analysis published in 2006 substantiates the use of ginger against postoperative nausea and vomiting. In five randomized trials with a total of 363 patients, ginger was more effective than placebo12. Fresh ginger juice powder and dry ginger hydro-ethanolic extract powder are found to be better for nausea, morning sickness and as a digestive aid at 100 to 250 mg dosage 3 or 4 times daily.
We isolate 6-gingerol rich ginger extract powder combining supercritical extraction methods with the state-of-the art spray drying techniques to offer free flowing 6-gingerol water soluble powder - Ginginoll®.
The unique extraction process without using any organic solvents helps to modulate the relative percentage of essential oil content to produce the extract with a varying degree of aroma profile. It is manufactured under GMP conditions and comes with the quantitative HPLC profiles of various active components and bioacative gingerols including 6, 8, 10 gingerol and shoagols. The formulation retains of all bioactive components at relevant physiological levels to provide highest degree of anti-oxidant/anti-inflammatory protection at cellular level (in house data). The thermal stability and water solubility also makes this ingredient suitable to incorporate in various food/beverages like juices, soft drinks, sachets, chocolates, protein bars, sports health supplements etc. We make sure the raw material from the same location, its unique post -harvest operations and complete scan of traceability to position Ginginoll®, as the unique gingerol extract with a difference, among the various commercially available extracts.
The statements made above have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
NutriSPICE® represents a unique range of various exotic healthy spice derived
antioxidants - extracted, concentrated and formulated as fully water soluble free flowing powders for
functional beverage applications. This patent pending extract, which is 100% natural and free from
emulsifiers are available with application data and possible marketing claims. Flavour and aroma can be
tailored to meet varying customer demands.
The statements made above have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Fenugreek (Trigonella foenum gracum) regarded as one of the nature's choice for women health.
FenuSMART™ is a unique patent pending composition of Fenugreek phytonutrients clinically validated
for postmenopausal management. This green standardized extract helps to reduce hot flashes, night sweat
sleep disorders, mood variations, etc by maintaining healthy hormonal levels as evident from the
clinical trial. FenuSMART™ also helps to keep healthy lipid profile. It also helps to
provide better serum calcium and hemoglobin levels without imparting any negative biochemical or
haematological effects or adverse effect upon 3 months studies.
A holistic extract of Fenugreek seeds (100%) standardised for a unique phytonutrients RATIO for the best efficacy and hormonal balance at OPTIMIZED LOW DOSAGE. Supported by two international patents and four randomized double-blinded placebo-controlled clinical trials on POST-, PERI- and HEALTHY women and publications in peer-reviewed journals.
The statements made above have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Patented FENUMAT™ technology transforms the oleo-gum-resin of Ferula asafoetida into sustained-release microgel beadlets for safe consumption and easy formulation for safe consumption.
The statements made above have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.